gene 1,561 words KG: YARS2
Contents

YARS2 — Tyrosyl-tRNA Synthetase 2, Mitochondrial

🧬 Gene Info
Gene SymbolYARS2
Full NameTyrosyl-tRNA Synthetase 2, Mitochondrial
Chromosome12p11.21
Protein TypeMitochondrial aminoacyl-tRNA synthetase
Functionencodes a mitochondrial aminoacyl-tRNA synthetase (mtaaRS) that catalyzes the attachment of tyrosine to its cognate mitochondrial tRNA during mitochondrial translation.
Subcellular Localizationor stability
Molecular Weight52 kDa
Amino Acids495 aa
Exons13
UniProt IDQ9Y2Z4
NCBI Gene ID51091
Ensembl IDENSG00000143398
OMIM613739
GeneCardsYARS2
Human Protein AtlasYARS2
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsHPASTRING

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Related Hypotheses (15)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53

Related Analyses (11)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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