| Gene Symbol | TRPC5 |
| Chromosome | Xq23 |
| Protein Type | Channel |
| Function | TRPC5 is a member of the TRPC (Transient Receptor Potential Canonical) family with unique neuronal expression patterns and functions. |
| Primary Expression | brain, particularly in hippocampal and cortical neurons [2](https://pubmed |
| Ensembl ID | ENSG00000120336 |
| GeneCards | TRPC5 |
| Human Protein Atlas | TRPC5 |
| Neuronal Specificity | Highly expressed in brain, particularly in hippocampal and cortical neurons 2 |
| Gating | Activated by GPCR signaling, receptor tyrosine kinases, and mechanical stimuli 3 |
| Synaptic Function | Regulates dendritic spine morphology, synaptic transmission, and plasticity 4 |
| Development | Critical for neuronal development, axon guidance, and dendrite morphogenesis 5 |
| Intellectual Disability | Loss-of-function mutations cause X-linked intellectual disability 6 |
| Autism Spectrum Disorder | TRPC5 variants identified in patients with ASD 7 |
| Epilepsy | De novo mutations associated with epileptic encephalopathy 8 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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