| Gene Symbol | TRPC4 |
| Chromosome | 13q13.3 |
| Protein Type | Channel |
| Function | TRPC4 forms non-selective cation channels that are primarily activated by G-protein-coupled receptor (GPCR) signaling through phospholipase C (PLC). |
| Primary Expression | the brain, particularly in hippocampal neurons, cortical pyramidal cells, and cerebellar granule cells [3](https://pubmed |
| Subcellular Localization | dendritic membranes and contributes to synaptic integration and plasticity [11](https://pubmed.ncbi.nlm.nih.gov/19139269 |
| Ensembl ID | ENSG00000133189 |
| GeneCards | TRPC4 |
| Human Protein Atlas | TRPC4 |
| Gating Mechanism | Activated by diacylglycerol (DAG) and mechanical stretch 2 |
| Expression Pattern | Widely expressed in the brain, particularly in hippocampal neurons, cortical pyramidal cells, and cerebellar granule cells 3 |
| Physiological Roles | Regulation of neuronal excitability, neurotransmitter release, synaptic plasticity, and neuroprotection 4 |
| Interaction Partners | Associates with TRPC5 to form heteromeric channels, interacts with calmodulin and PLC isoforms 5 |
| Epilepsy | Modulation of TRPC4 activity may reduce seizure frequency 13 |
| Anxiety Disorders | Reduced TRPC4 expression associated with anxiety-like behaviors in mouse models 7 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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