gene 1,779 words KG: TMEM65
Contents

TMEM65 Gene

🧬 Gene Info
Gene SymbolTMEM65
Full NameTransmembrane Protein 65
Chromosome8q24.3
Functionencodes a mitochondrial inner membrane protein that plays critical roles in oxidative phosphorylation, mitochondrial complex I assembly, and metabolic regulation.
Primary ExpressionHeart, brain (neurons), skeletal muscle, liver, kidney
Subcellular Localizationthe mitochondrial inner membrane, with both N- and C-termini facing the mitochondrial matrix
Molecular Weight43.5 kDa
Amino Acids384 aa
Exons4
UniProt IDQ9P0M4
NCBI Gene ID65078
Ensembl IDENSG00000143357
OMIM616613
GeneCardsTMEM65
Human Protein AtlasTMEM65
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsHPASTRING

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Related Hypotheses (26)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
CYP46A1 Overexpression Gene Therapy
Score: 0.98
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
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Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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