gene 652 words KG: TFEC
Contents

TFEC Gene

🧬 Gene Info
Gene SymbolTFEC
Full NameTranscription Factor EC
Chromosome6p21.1
Protein FamilybHLH-Zip (MITF/TFEB/TFE3/TFEC)
FunctionLysosomal biogenesis, autophagy regulation
Primary ExpressionMicroglia, brain macrophages
Pathwayspathway: ```mermaid, mTOR
GeneCardsTFEC
Human Protein AtlasTFEC
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (18)

APOE-Dependent Autophagy Restoration
Score: 0.89
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Orexin-Microglia Modulation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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