gene 1,385 words KG: TFB2M
Contents

TFB2M — Mitochondrial Transcription Factor B2

🧬 Gene Info
Gene SymbolTFB2M
Full NameMitochondrial Transcription Factor B2
Protein TypeTranscription Factor
Functionencodes a mitochondrial protein that functions as a transcription factor and methyltransferase essential for mitochondrial gene expression.
Amino Acids420 aa
Ensembl IDENSG00000162836
GeneCardsTFB2M
Human Protein AtlasTFB2M
13 OXPHOS proteinsComponents of the electron transport chain (7 subunits of complex I, 1 of III, 3 of IV, 2 of V)
2 rRNAs12S and 16S rRNA for mitochondrial ribosomes
22 tRNAsRequired for mitochondrial translation
Heavy-strand promoter (HSP)Transcribes most genes including rRNAs
Light-strand promoter (LSP)Transcripts serve as primers for replication and encode ND6
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (10)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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