| Gene Symbol | TACR1 |
| Full Name | Tachykinin Receptor 1 |
| Chromosome | 2p12 |
| Function | NK1 receptor antagonists may have cognitive-enhancing effects |
| Primary Expression | the central and peripheral nervous systems and plays important roles in pain transmission, neuroinflammation, mood regulation, and stress responses[@h |
| Pathways | MAPK |
| GeneCards | TACR1 |
| Human Protein Atlas | TACR1 |
| Extracellular N-terminus | Contains ligand-binding sites |
| Transmembrane domains | Seven alpha-helices spanning the membrane |
| Intracellular C-terminus | Couples to G proteins and contains phosphorylation sites |
| Ligand binding | High affinity for substance P (SP), with lower affinity for neurokinin A and B |
| Gαq/11 | Activates phospholipase C (PLC) |
| IP3 production | Leads to intracellular Ca2+ release |
| DAG formation | Activates protein kinase C (PKC) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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