| Gene Symbol | SCN3A |
| Aliases | Sodium Voltage-Gated Channel Alpha Subunit 3 |
| Protein Type | Gene |
| Function | SCN3A encodes Nav1.3, a voltage-gated sodium channel alpha subunit that mediates the inward sodium current (I_Na) essential for action potential generation and propagation. |
| Primary Expression | the central nervous system during development |
| Molecular Weight | 260 kDa |
| GeneCards | SCN3A |
| Human Protein Atlas | SCN3A |
| Channel Type | Voltage-gated sodium channel (Nav1.3) |
| Primary Structure | Large transmembrane protein with 4 repeat domains (I-IV), each containing 6 transmembrane segments (S1-S6) |
| Gating | Rapid activation and inactivation kinetics |
| Expression Pattern | High in embryonic and early postnatal brain, upregulated in injured neurons and pathological conditions |
| Brain | Higher expression during development, persists in thalamus, cortex, and hippocampus |
| Spinal Cord | Dorsal horn neurons involved in pain transmission |
| Peripheral Nervous System | Limited expression in adult sensory neurons |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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