| Gene Symbol | RPS26 |
| Full Name | Ribosomal Protein S26 |
| Chromosome | 12p13.31 |
| Protein Type | Gene |
| Function | is a component of the 40S ribosomal subunit and plays essential roles in protein synthesis, ribosome biogenesis, and cellular stress response[@rps26_structure_2020]. |
| Molecular Weight | 13 kDa |
| Amino Acids | 119 aa |
| GeneCards | RPS26 |
| Human Protein Atlas | RPS26 |
| mRNA recruitment | RPS26 contributes to the proper positioning of the 43S complex on the 5' cap structure |
| Scanning optimization | The protein helps maintain the scanning competence of the 40S subunit |
| Start codon recognition | RPS26 participates in the final steps of AUG codon recognition |
| Reduced ribosomal protein expression | Post-mortem brain analysis of AD patients shows decreased RPS26 and other ribosomal protein levels in vulnerable regions including hippocampus and entorhinal cortex |
| Translation impairment | Global protein synthesis is reduced in AD brain, correlating with cognitive decline |
| Ribosomal stress response | Activation of the p53-mediated stress response has been observed in AD neurons, potentially linked to ribosomal dysfunction |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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