gene 1,981 words KG: QARS
Contents

QARS — Glutaminyl-tRNA Synthetase

🧬 Gene Info
Gene SymbolQARS
Full NameGlutaminyl-tRNA Synthetase
Chromosome3p21.31
Protein TypeSynthetase
Functionencodes a member of the class I tRNA synthetase family that catalyzes the ATP-dependent attachment of L-glutamine to the 3' end of tRNA^Gln.
Primary Expressionboth neurons and glia, with particular abundance in cerebellar Purkinje cells, hippocampal neurons, and cortical pyramidal neurons
Molecular Weight64 kDa
Amino Acids582 aa
Exons26
UniProt IDP47820
NCBI Gene ID5859
Ensembl IDENSG00000172046
OMIM613727
GeneCardsQARS
Human Protein AtlasQARS
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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Related Hypotheses (10)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
RNA Granule Nucleation Site Modulation
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.88
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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