| Gene Symbol | PRRT2 |
| Full Name | Proline-Rich Transmembrane Protein 2 |
| Chromosome | 16p11.2 |
| Function | encodes a neuronal protein critically involved in synaptic transmission and neurotransmitter release. |
| Amino Acids | 340 aa |
| UniProt ID | [Q7Z405](https://www.uniprot.org/uniprot/Q7Z405) |
| Ensembl ID | ENSG00000146859 |
| GeneCards | PRRT2 |
| Human Protein Atlas | PRRT2 |
| Synaptic vesicle release modulation | PRRT2 regulates the probability of neurotransmitter release by interacting with the SNARE complex[@gardoni2019] |
| SNAP25 interaction | Direct binding to SNAP25 modulates SNARE complex assembly |
| Synaptotagmin binding | Interaction with synaptotagmin-1 links PRRT2 to calcium-dependent release |
| Vesicle recycling | PRRT2 participates in synaptic vesicle endocytosis and recycling[@zhang2022] |
| Brain | Highest expression in cerebral cortex, basal ganglia (particularly striatum), and cerebellum[@cilia2022] |
| Spinal cord | Moderate expression in motor neurons |
| Associated Diseases | Parkinson's disease, Alzheimer's disease, Epilepsy |
| Databases | GeneCardsNCBI GeneHPASTRING |
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