| Gene Symbol | PPP2R5B |
| Chromosome | 14q32.31 |
| Protein Type | Gene |
| Function | encodes a protein of approximately 515 amino acids. |
| Primary Expression | the human brain with highest levels in: - Hippocampus (CA1-CA3 regions, dentate gyrus): Critical for memory circuits - Cerebral cortex (layer |
| Subcellular Localization | This trimeric structure allows precise temporal and spatial regulation of PP2A activity toward specific substrates inclu |
| Amino Acids | 515 aa |
| Exons | 14 |
| GeneCards | PPP2R5B |
| Human Protein Atlas | PPP2R5B |
| N-terminal region | Contains the conserved B56 domain (~150 amino acids) responsible for substrate binding and PP2A targeting |
| Central region | Contains multiple HEAT repeats involved in protein-protein interactions |
| C-terminal region | Mediates interaction with the PP2A catalytic and scaffolding subunits |
| Catalytic subunit (PP2AC/PPP2CA) | The active phosphatase component |
| Scaffold subunit (PPP2R1A/PR65A) | Provides structural framework |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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