| Gene Symbol | PPP2R1A |
| Full Name | Protein Phosphatase 2 Regulatory Subunit A Alpha |
| Chromosome | 19q13.41 |
| Function | PPP2R1A encodes the alpha isoform of the PP2A subunit A, which serves as a scaffold for assembling the PP2A holoenzyme. |
| Pathways | PI3K, MAPK, Wnt |
| UniProt ID | P46821 |
| NCBI Gene ID | 5518 |
| Ensembl ID | ENSG00000101162 |
| OMIM | 616981 |
| GeneCards | PPP2R1A |
| Human Protein Atlas | PPP2R1A |
| Tau dephosphorylation | PP2A dephosphorylates tau at multiple pathological sites (Ser202, Thr205, Ser396, Ser404) |
| Signal transduction | Regulates various signaling pathways including PI3K/Akt, MAPK, and Wnt |
| Cell cycle control | Essential for cell cycle progression |
| Synaptic plasticity | Regulates NMDA receptor function and LTP |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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