gene 822 words KG: PET100
Contents

PET100 — Protein PET100 Homolog (Mitochondrial)

🧬 Gene Info
Gene SymbolPET100
Full NameProtein PET100 Homolog (Mitochondrial)
AliasesPET100 Protein
Functionis a small mitochondrial protein that plays a critical role in the assembly of cytochrome c oxidase (Complex IV) of the mitochondrial respiratory chain.
Molecular Weight10 kDa
Amino Acids79 aa
Ensembl IDENSG00000167701
GeneCardsPET100
Human Protein AtlasPET100
N-terminal targeting sequenceMitochondrial import signal
Core domainRequired for Complex IV assembly
Interaction surfacesBinds to other assembly factors
Early assemblyAssociates with early COX assembly intermediates
Heme incorporationHelps incorporate heme a and heme a3
Subunit recruitmentFacilitates incorporation of nuclear-encoded subunits
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (15)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (13)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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