| Gene Symbol | PDE1B |
| Full Name | Phosphodiesterase 1B |
| Chromosome | 21q22.11 |
| Function | is a 536-amino acid protein with a characteristic phosphodiesterase domain structure |
| Primary Expression | Brain (striatum, hippocampus, cortex) |
| Amino Acids | 536 aa |
| UniProt ID | [Q01065](https://www.uniprot.org/uniprot/Q01065) |
| Ensembl ID | ENSG00000184518 |
| OMIM | 607323 |
| GeneCards | PDE1B |
| Human Protein Atlas | PDE1B |
| Basal state | In the absence of elevated calcium, PDE1B has minimal activity |
| Calcium influx | When neuronal activity increases intracellular calcium, calcium-bound calmodulin activates PDE1B |
| Signal termination | Activated PDE1B rapidly hydrolyzes cAMP/cGMP, effectively terminating the signal |
| Reset | When calcium returns to baseline, calmodulin dissociates and PDE1B returns to the inactive state |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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