| Gene Symbol | PARD6G |
| Full Name | Partitioning Defect 6 Par-6 Family Cell Polarity Protein Gamma |
| Chromosome | 18q22.1 |
| Function | encodes a component of the PAR (Partitioning Defect) polarity complex, a key regulator of cell polarity in eukaryotic cells[@ridley2019]. |
| Primary Expression | both excitatory and inhibitory neurons throughout the brain, with particularly high levels in the hippocampus and cerebral cortex |
| Molecular Weight | 38 kDa |
| Amino Acids | 346 aa |
| Exons | 10 |
| GeneCards | PARD6G |
| Human Protein Atlas | PARD6G |
| N-terminal PDZ domain | Mediates interactions with polarity proteins and membrane receptors |
| C-terminal semi-CRIB domain | Required for CDC42/Rac interaction |
| Polyproline region | Involved in protein-protein interactions |
| S/T-rich C-terminal tail | Site of regulatory phosphorylation |
| PARD6A | Ubiquitous expression, highest in epithelial tissues |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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