| Gene Symbol | MAP3K3 |
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 3 |
| Chromosome | 17q23 |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that serves as a critical upstream activator of both the NF-κB and MAPK signaling pathways. |
| Subcellular Localization | The protein exists in an autoinhibited conformation in resting cells, with the kinase domain held in an inactive state b |
| Pathways | NF-κB, MAPK signaling, MAPK, NF-κB pathway |
| UniProt ID | [Q99731](https://www.uniprot.org/uniprot/Q99731) |
| Ensembl ID | ENSG00000106803 |
| OMIM | 603013 |
| GeneCards | MAP3K3 |
| Human Protein Atlas | MAP3K3 |
| Cytoplasmic | Majority in resting cells |
| Membrane-proximal | Associates with signaling complexes upon activation |
| Nuclear | Translocates for some transcriptional responses |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
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