| Gene Symbol | WASHC5 (formerly KIAA0196) |
| Full Name | WASH Complex Subunit 5 (Strumpellin) |
| Chromosome | 8q24.13 |
| Function | encodes a core component of the WASH complex that regulates endosomal protein sorting and recycling. |
| Amino Acids | 159 aa |
| UniProt ID | Q12768 |
| NCBI Gene ID | 9744 |
| Ensembl ID | ENSG00000104523 |
| OMIM | 610657 |
| Cargo sorting | Enables recycling of cell surface receptors (transferrin receptor, integrins, glucose transporters) from endosomes back to the plasma membrane |
| Retromer cooperation | WASH complex works with the retromer (VPS35) to sort cargo from endosome-to-Golgi and endosome-to-surface pathways |
| Membrane remodeling | Actin-driven tubulation creates recycling tubules from endosomal compartments |
| Receptor trafficking | Required for proper trafficking of signaling receptors in neurons |
| Axonal transport | Long corticospinal axons require efficient endosomal trafficking |
| Synaptic receptor recycling | AMPA and NMDA receptor surface expression depends on endosomal sorting |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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