| Gene Symbol | KCNH5 |
| Chromosome | 14q23.1 |
| Protein Type | Gene |
| Function | encodes a protein of 989 amino acids forming the core alpha subunit of the EAG2 potassium channel. |
| Primary Expression | striatal neurons |
| Amino Acids | 989 aa |
| Exons | 16 |
| GeneCards | KCNH5 |
| Human Protein Atlas | KCNH5 |
| N-terminal Per-Arnt-Sim (PAS) domain | Senses voltage and redox state |
| Voltage sensor domain (VSD) | Segments S1-S4 detect membrane potential changes |
| Pore domain | Segments S5-S6 form the K+ selectivity filter |
| Leucine zipper motif | Facilitates tetramerization |
| Tetrameric assembly | Four alpha subunits form the pore |
| Auxiliary subunits | May associate with beta subunits |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!