| Gene Symbol | IARS2 |
| Full Name | Isoleucyl-tRNA Synthetase 2, Mitochondrial |
| Chromosome | 9q33 |
| Protein Type | Gene |
| Function | is a nuclear-encoded gene located on chromosome 9q33 that encodes a mitochondrial aminoacyl-tRNA synthetase (aaRS). |
| Amino Acids | 842 aa |
| Exons | 23 |
| GeneCards | IARS2 |
| Human Protein Atlas | IARS2 |
| Brain | Particularly in cortical neurons, cerebellar Purkinje cells, and retinal ganglion cells |
| Heart | Continuous high energy demand |
| Skeletal muscle | Variable, increases with exercise and training |
| Liver | High metabolic activity |
| Kidney | High metabolic and transport activity |
| Mitochondrial targeting sequence (MTS) | N-terminal 50-60 amino acid cleavable signal peptide |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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