| Gene Symbol | HTR1E |
| Full Name | 5-Hydroxytryptamine Receptor 1E |
| Chromosome | 6q14.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various brain regions including the frontal cortex, hippocampus, and basal ganglia, areas criti |
| UniProt ID | P28566 |
| NCBI Gene ID | 3354 |
| GeneCards | HTR1E |
| Human Protein Atlas | HTR1E |
| G protein coupling | Gi/o-coupled, inhibiting adenylyl cyclase |
| Signal transduction | Decreases intracellular cAMP levels |
| Ligand binding | High affinity for serotonin (5-HT) and various serotonergic drugs |
| Receptor distribution | Prefrontal cortex, hippocampus, basal ganglia, dorsal raphe nucleus |
| Schizophrenia | Altered 5-HT1E binding has been reported in prefrontal cortex <sup>11</sup> |
| Migraine | 5-HT1E receptors are targeted by serotonergic migraine therapeutics <sup>12</sup> |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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