gene 1,124 words KG: HERPUD1
Contents

HERPUD1 — Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Protein 1

🧬 Gene Info
Gene SymbolHERPUD1
Full NameHomocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Protein 1
Chromosome16q13
Functionis a critical ER membrane protein involved in ER-associated degradation (ERAD) and the unfolded protein response (UPR).
Molecular Weight46 kDa
Amino Acids390 aa
UniProt IDQ9Y5X5
NCBI Gene ID9709
Ensembl IDENSG00000128604
OMIM607340
GeneCardsHERPUD1
Human Protein AtlasHERPUD1
Associated DiseasesParkinson's disease, Alzheimer's disease
DatabasesGeneCardsHPASTRING

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Related Hypotheses (11)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.92
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (9)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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