| Gene Symbol | GPR173 |
| Aliases | SREB3 |
| Function | encodes a 353-amino acid GPCR belonging to the Class A rhodopsin family. |
| Primary Expression | Brain) family in 2000 by Matsumoto et al |
| Amino Acids | 353 aa |
| Ensembl ID | ENSG00000146373 |
| GeneCards | GPR173 |
| Human Protein Atlas | GPR173 |
| Transmembrane domains 1-7 | Seven alpha-helices spanning the membrane |
| Extracellular loops | ECL1, ECL2, ECL3 involved in ligand binding |
| Intracellular loops | ICL1, ICL2, ICL3 coupling to G proteins |
| C-terminal tail | Contains serine/threonine residues for phosphorylation |
| Cortex | Highest expression in layers II-III and V, important for cognitive function |
| Hippocampus | Dense expression in CA1-CA3 pyramidal neurons and dentate gyrus granule cells |
| Basal ganglia | Moderate expression in striatum and substantia nigra |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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