| Gene Symbol | GCH2 |
| Full Name | GTP Cyclohydrolase II |
| Protein Type | Hydrolase |
| Function | is an essential cofactor for aromatic amino acid hydroxylases (tyrosine hydroxylase, tryptophan hydroxylase, phenylalanine hydroxylase) and nitric oxide synthases. |
| Primary Expression | both dopaminergic cell bodies in the substantia nigra and their terminals in the striatum, ensuring local BH4 production at both sites of dopamine syn |
| Ensembl ID | ENSG00000163040 |
| GeneCards | GCH2 |
| Human Protein Atlas | GCH2 |
| Transcriptional regulation | GCH2 expression is induced by cytokines, growth factors, and neuronal activity |
| Allosteric regulation | Product inhibition by BH4 provides feedback control |
| Post-translational modification | Phosphorylation can modulate enzyme activity |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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