gene 1,507 words KG: ERCC9
Contents

ERCC9 (FANCN) - DNA Repair and Neurodegeneration

🧬 Gene Info
Gene SymbolERCC Excision Repair 9, Complementing
Aliasesalso known as FANCN
Chromosome9q33.2
Protein TypeDNA Repair Protein, Fanconi Anemia Pathway
Functionencodes a DNA repair protein essential for the Fanconi anemia pathway and transcription-coupled nucleotide excision repair (TC-NER)[@bogliolo2007].
Amino Acids462 aa
UniProt IDQ8IYD1
NCBI Gene ID2075
Ensembl IDENSG00000135821
OMIM614721
BrainNeurons in cortex, hippocampus, and basal ganglia
Bone marrowHematopoietic stem and progenitor cells
LiverHepatocytes
KidneyTubular epithelial cells
TestisSpermatogenic cells
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (139)

Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Complement C1q Subtype Switching
Score: 0.66
RNA Granule Nucleation Site Modulation
Score: 0.66
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65
Microbial Inflammasome Priming Prevention
Score: 0.65
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
Nucleolar Stress Response Normalization
Score: 0.65
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
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Related Analyses (26)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · completed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypotheses
China Neurodegeneration Epidemiology
disease · Pages share 139 hypotheses
Neuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

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