gene 1,507 words KG: ERCC9
Contents

ERCC9 (FANCN) - DNA Repair and Neurodegeneration

🧬 Gene Info
Gene SymbolERCC Excision Repair 9, Complementing
Aliasesalso known as FANCN
Chromosome9q33.2
Protein TypeDNA Repair Protein, Fanconi Anemia Pathway
Functionencodes a DNA repair protein essential for the Fanconi anemia pathway and transcription-coupled nucleotide excision repair (TC-NER)[@bogliolo2007].
Amino Acids462 aa
UniProt IDQ8IYD1
NCBI Gene ID2075
Ensembl IDENSG00000135821
OMIM614721
BrainNeurons in cortex, hippocampus, and basal ganglia
Bone marrowHematopoietic stem and progenitor cells
LiverHepatocytes
KidneyTubular epithelial cells
TestisSpermatogenic cells
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (139)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
SASP-Mediated Complement Cascade Amplification
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
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Related Analyses (26)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · completed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypotheses
China Neurodegeneration Epidemiology
disease · Pages share 139 hypotheses
Neuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

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