gene 3,363 words KG: EPHA6
Contents

EPHA6 — Ephrin Type-A Receptor 6

🧬 Gene Info
Gene SymbolEPHA6
Full NameEphrin Type-A Receptor 6
Chromosome3q21.1
Protein TypeReceptor
Functionis a member of the Eph family of receptor tyrosine kinases that play critical roles in development and plasticity of the central nervous system[@kawasaki2006].
Primary ExpressionCortex, hippocampus, cerebellum, basal ganglia
Molecular Weight110 kDa
Amino Acids550 aa
Exons17
UniProt IDQ9Y232
NCBI Gene ID28534
Ensembl IDENSG00000048028
GeneCardsEPHA6
Human Protein AtlasEPHA6
Associated DiseasesAlzheimer's Disease, Parkinson's Disease
DatabasesGeneCardsHPASTRING

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Related Hypotheses (20)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
nct05508789
clinical_trial · Pages share 4 hypotheses
MK-1167 Phase 2 AD Trial (MK-1167-008)
clinical · Pages share 4 hypotheses
A Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 4 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 4 hypotheses

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