| Gene Symbol | EDEM2 |
| Full Name | ER Degradation Enhancer |
| Chromosome | 7p22.1 |
| Protein Type | Gene |
| Function | is a key regulator of endoplasmic reticulum-associated degradation (ERAD). |
| Primary Expression | all tissues with high expression in: - Brain: Neurons, astrocytes, microglia - |
| Subcellular Localization | Endoplasmic reticulum membrane |
| Amino Acids | 639 aa |
| GeneCards | EDEM2 |
| Human Protein Atlas | EDEM2 |
| ER stress | Dopaminergic neurons are particularly sensitive to ER stress |
| [Tau](/proteins/tau) pathology | EDEM2 dysfunction may contribute to tau aggregation |
| Adaptive response | EDEM2 is upregulated in AD brain as a protective response |
| Protein aggregation | EDEM2 dysfunction may contribute to Lewy body formation |
| ER stress response | Motor neurons experience chronic ER stress |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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