| Gene Symbol | EARS2 |
| Full Name | Mitochondrial Glutamyl-tRNA Synthetase |
| Protein Type | Synthetase |
| Function | is an essential mitochondrial aminoacyl-tRNA synthetase (mtARS) that catalyzes the charging of glutamate to its cognate mitochondrial tRNA. |
| Amino Acids | 200 aa |
| Ensembl ID | ENSG00000120784 |
| GeneCards | EARS2 |
| Human Protein Atlas | EARS2 |
| Aminoacylation domain | The active site that catalyzes glutamate activation and tRNA charging |
| ATP-binding pocket | Conserved KMSKS loop that binds ATP |
| acceptor stem binding region | Recognizes the 3' end of tRNA |
| Helical domain | Mediates protein-protein interactions |
| Dimerization interface | EARS2 functions as a dimer |
| tRNA recognition elements | Additional binding surfaces for tRNA specificity |
| Rossmann fold | Central β-sheet with α-helices in catalytic domain |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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