| Gene Symbol | DUSP5 |
| Protein Type | Phosphatase |
| Function | is a nuclear-localized dual-specificity phosphatase that specifically dephosphorylates and inactivates ERK1/2 MAP kinases. |
| Subcellular Localization | DUSP5 is exclusively nuclear, unlike most other DUSPs which are cytosolic. This nuclear localization is mediated by: |
| Amino Acids | 382 aa |
| Pathways | MAPK pathway |
| Ensembl ID | ENSG00000100647 |
| GeneCards | DUSP5 |
| Human Protein Atlas | DUSP5 |
| N-terminal Non-catalytic Domain | Mediates nuclear localization and protein interactions |
| Phosphatase Domain | Contains the HCX5R motif essential for catalytic activity |
| Nuclear Localization Signal (NLS) | Directs DUSP5 to the nucleus |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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