| Gene Symbol | DNAJC31 |
| Protein Type | Chaperone |
| Function | is a member of the DnaJ/Hsp40 family of co-chaperones involved in cellular protein quality control pathways. |
| Primary Expression | various tissues, with expression in the brain suggesting potential roles in neuronal protein homeostasis |
| Molecular Weight | 32 kDa |
| Amino Acids | 298 aa |
| GeneCards | DNAJC31 |
| Human Protein Atlas | DNAJC31 |
| Glycine-rich flexible region | A flexible linker region between the J domain and C-terminal regions that facilitates protein-protein interactions and provides structural flexibility. |
| C-terminal client-binding domain | The C-terminal region is predicted to be involved in recognizing and binding unfolded or misfolded client proteins, containing regions that may form coiled-coil structures. |
| Brain | Expressed in various brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum. Both neuronal and glial cell expression has been detected. |
| Peripheral tissues | Moderate expression in heart, liver, kidney, and skeletal muscle. |
| Cellular localization | Primarily cytosolic localization, consistent with roles in general protein quality control throughout the cell. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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