| Gene Symbol | CLCN2 |
| Full Name | Chloride Voltage-Gated Channel 2 |
| Chromosome | 3q27.1 |
| Function | The CLCN2 gene encodes the chloride voltage-gated channel 2 (ClC-2), a voltage-gated chloride channel belonging to the CLC channel/transporter family. |
| Primary Expression | neurons and glia, involved in neuronal excitability, cell volume regulation, and GABAergic inhibition |
| Subcellular Localization | presynaptic terminals and postsynaptic densities, where it modulates synaptic transmission. It influences GABAergic inhi |
| UniProt ID | [P51788](https://www.uniprot.org/uniprot/P51788) |
| Ensembl ID | ENSG00000110958 |
| GeneCards | CLCN2 |
| Human Protein Atlas | CLCN2 |
| Cerebellum | Purkinje cells and granule cells |
| Thalamus | Relay neurons |
| Substantia nigra | Dopaminergic neurons |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!