| Gene Symbol | CHRM2 |
| Full Name | Muscarinic Acetylcholine Receptor M2 |
| Protein Type | Receptor |
| Function | The Muscarinic Acetylcholine Receptor M2 (CHRM2) is a G protein-coupled receptor (GPCR) that mediates the effects of acetylcholine on slow inhibitory postsynaptic potentials in the heart, smooth muscl |
| Primary Expression | the hippocampus, cerebral cortex, and basal ganglia, where it modulates learning, memory, and r |
| Ensembl ID | ENSG00000131617 |
| GeneCards | CHRM2 |
| Human Protein Atlas | CHRM2 |
| Hippocampus | highest in CA3 region and dentate gyrus |
| Cerebral cortex | layers II-III and V-VI |
| Basal ganglia | striatum and globus pallidus |
| Thalamus | relay nuclei |
| Heart | atrial and ventricular myocardium |
| Smooth muscle | gastrointestinal tract, bladder |
| Xanomeline | M1/M4 preferring agonist, investigated for AD |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!