| Gene Symbol | BICD1 |
| Full Name | Bicaudal D1 |
| Protein Type | Gene |
| Function | is a cytoskeletal adaptor protein that plays essential roles in intracellular transport, neuronal development, and synaptic function. |
| GeneCards | BICD1 |
| Human Protein Atlas | BICD1 |
| Coiled-coil domains | Multiple coiled-coil regions throughout the protein mediate homodimerization and interactions with dynein-dynactin |
| Dynein binding domain (DBD) | C-terminal region that directly binds to dynein light chains (DYNLT1/2/3) |
| Dynactin binding site | N-terminal region that interacts with the p150^Glued subunit of dynactin |
| Cargo-binding domains | Central regions that recognize specific cargo adaptors and vesicles |
| Microtubule orientation | Neuronal microtubules are oriented with plus ends toward synapses and minus ends toward the cell body |
| Retrograde direction | Dynein-dynactin moves cargo toward the minus end (cell body direction) |
| Processive movement | Single dynein-dynactin complexes can traverse micrometer-scale distances along microtubules |
| Motor coordination | BICD1 helps coordinate multiple motors for efficient cargo transport |
| Synaptic vesicle precursors | Transport of newly synthesized synaptic proteins from the cell body to presynaptic terminals |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!