| Gene Symbol | GALECTIN3 |
| Full Name | Galectin-3 |
| Chromosome | 14q22.3 |
| Protein Type | Protein |
| Function | is a member of the galectin family of beta-galactoside-binding lectins that plays a multifaceted role in neurodegenerative disease pathogenesis. |
| Primary Expression | microglia, the resident immune cells of the brain, where it serves as a key marker of disease-associated microglia (DAM) or neurodegenerative microgli |
| Exons | 6 |
| UniProt ID | Search UniProt |
| GeneCards | GALECTIN3 |
| Human Protein Atlas | GALECTIN3 |
| C-terminal tail | Critical for lectin activity and multimerization |
| Microglia | Low baseline expression, dramatically upregulated in disease states |
| Astrocytes | Moderate expression in reactive astrocytes |
| Neurons | Minimal expression under normal conditions |
| Plaque association | Galectin-3 colocalizes with Aβ plaques in AD brain tissue, indicating direct binding to Aβ aggregates |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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