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disease 1,205 words KG: ent-dise-76f5528d
Contents

Frontotemporal Dementia with Parkinsonism linked to Chromosome 17 (FTDP-17)

Disease Info
Frontotemporal atrophyParticularly affecting the frontal and anterior temporal lobes
Neuronal loss and gliosisIn affected cortical regions and subcortical structures
Substantia nigra degenerationLoss of dopaminergic neurons
Basal ganglia involvementVariable involvement of caudate nucleus, putamen, and globus pallidus
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (6)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60TREM2-mediated microglial tau clearance enhancement
Score: 0.59

Related Analyses (3)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedMetabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

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