| Sleep disturbance | Difficulty falling asleep or staying asleep due to leg discomfort |
| Periodic limb movements | Involuntary leg movements during sleep (PLMS) in up to 80% of patients |
| Daytime fatigue | Resulting from sleep disruption |
| Mood changes | Depression and anxiety are common comorbidities |
| Sleep study (polysomnography) | To detect periodic limb movements and assess sleep architecture |
| Iron studies | Serum ferritin, transferrin, iron saturation |
| Neurological examination | To rule out peripheral neuropathy |
| Blood tests | Kidney function, thyroid function, glucose, vitamin B12, folate |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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