| Motor impairment | Asymmetric rigidity, bradykinesia, dystonia, and myoclonus severely limit daily activities |
| Mobility | Progressive gait disturbance leads to falls, dependence on assistive devices, and eventual wheelchair use |
| Self-care | Dressing, grooming, bathing, and feeding become increasingly difficult |
| Communication | Speech and voice changes impact daily conversations and social interactions |
| Depression | Prevalence of clinically significant depression ranges from 30-50% |
| Anxiety | Related to disease progression, functional decline, and uncertainty about the future |
| Apathy | Common in CBS, often mistaken for depression |
| Frustration and grief | Loss of independence and identity as disease progresses |
| Social isolation | Progressive disability limits ability to participate in social activities |
| Role changes | Patients transition from caregivers or breadwinners to care recipients |
| Relationship strain | Family and friend relationships often become strained |
| Work disability | Most patients must stop working within 2-3 years of diagnosis |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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