disease 1,662 words KG: ent-dise-e20a7e2e
Contents

PSP-CBD Overlap Syndrome

Disease Info
CBDDescribed as a progressive asymmetric movement disorder with apraxia, cortical sensory loss, and alien limb phenomenon
Globose neurofibrillary tanglesLocated in subthalamic nucleus, globus pallidus, substantia nigra
Tufted astrocytesParticularly in the striatum and cortex
Coiled bodiesOligodendroglial tau inclusions
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (2)

Multi-Modal Stress Response Harmonization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75

Related Analyses (6)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (18)

Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40
4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Tau Pathology Initiation Zone Identification
clinical · proposed · Score: 0.40
Tau Spreading Network Mapping via Spatial Transcriptomics in
clinical · proposed · Score: 0.40
Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.40

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