disease 3,312 words KG: ent-dise-4d1cc4ef
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Progressive Supranuclear Palsy

Disease Info
Cognitive impairmentExecutive dysfunction, slowed processing speed
Speech difficultiesDysarthria, reduced speech volume
Swallowing problemsDysphagia, risk of aspiration
Sleep disturbancesREM sleep behavior disorder
Urinary dysfunctionUrgency, frequency
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (14)

Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Smartphone-Detected Motor Variability Correction
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Microglial Purinergic Reprogramming
Score: 0.70
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Sphingolipid Metabolism Reprogramming
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
APOE Isoform Expression Across Glial Subtypes
Score: 0.74

Related Analyses (11)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Viral and Post-Infectious Mechanisms in ALS — Experiment Des
clinical · proposed · Score: 0.40
Tau Spreading Network Mapping via Spatial Transcriptomics in
clinical · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40
Tau ASO Therapy
validation · proposed · Score: 0.40
s:** - Test tau spreading in AQP4 knockout vs wild-type mice
falsification · proposed · Score: 0.40

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