disease 3,290 words KG: ent-dise-bac7d871
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Posterior Cortical Atrophy

Disease Info
Visual acuity problemsDespite normal eye examinations, patients report difficulty reading, especially small print
Object recognition deficitsDifficulty identifying objects, faces (prosopagnosia), and places
Spatial disorientationProblems with navigation, judging distances, and finding items in familiar environments
Reading difficultyLetters seem to move or disappear, difficulty following lines of text
Color perception changesReduced ability to perceive and differentiate colors
Visuospatial neglectInattention to one side of visual space
Elemental visual disturbancesDifficulty with motion perception, depth perception, and form discrimination
SimultagnosiaInability to perceive more than one object at a time, leading to difficulty with complex visual scenes
Optic ataxiaDifficulty reaching for objects under visual guidance, with misreaching to targets
Gaze apraxiaDifficulty voluntarily directing gaze toward objects, requiring head movements to compensate
AgraphiaDifficulty writing, particularly with letter formation
AcalculiaDifficulty with arithmetic calculations, even with simple operations
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (11)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (4)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40
Sex Differences in Alzheimer's Disease — mechanisms and ther
clinical · proposed · Score: 0.40

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