| Cognitive decline | Progressive presenile dementia resembling Alzheimer's Disease |
| Behavioral changes | Frontal lobe syndrome with personality alterations, loss of social inhibitions, aggressive behavior |
| Mood disturbances | Euphoria, apathy, depression |
| Speech disorders | Dysarthria, eventual mutism |
| Motor symptoms | Upper motor neuron signs including spasticity, myoclonus, gait disturbance |
| Seizures | Generalized tonic-clonic seizures |
| Agnosia and apraxia | Loss of sensory and motor planning abilities |
| Memory impairment | Progressive forgetfulness and cognitive deficits |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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