| Prevalence | 1-2 per 100,000 population 4 |
| Age of onset | Typically 20-50 years (mean: 40 years) |
| Gender distribution | Male predominance (M:F = 2.5:1) |
| Geographic distribution | Worldwide, no ethnic predominance |
| Disease course | Chronic progressive, typically over years |
| Geographic variation | Relatively consistent worldwide |
| Familial cases | Extremely rare (sporadic is the rule) |
| Associated conditions | Occasionally associated with other autoimmune disorders |
| Target | GM1 ganglioside on peripheral nerve myelin |
| Correlation | Higher antibody titers correlate with more severe conduction block |
| Specificity | Not absolute—anti-GM1 also seen in other neuropathies |
| T-cell mediated demyelination | Perivascular T-cell infiltrates in nerve biopsies 9 |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!