disease 1,622 words KG: ent-dise-720d2d46
Contents

FTD Subtype Comparison Matrix — bvFTD vs svPPA vs nfPPA vs logopenic

Disease Info
AnomiaWord-finding difficulty, particularly for low-frequency items
Single-word Comprehension DeficitLoss of word meaning, especially for objects
Surface DyslexiaReading words with irregular pronunciation
Object AgnosiaInability to recognize objects despite intact vision
Preserved Speech FluencyFluent, grammatically correct speech with empty content
Preserved RepetitionNormal repetition ability
AgrammatismOmission of function words, simplified grammar, short phrases
Hesitant/Slow SpeechEffortful, halting speech production
Phonological ErrorsSound-level errors (substitutions, transpositions)
Motor Speech ImpairmentApraxia of speech
Preserved Word ComprehensionUnderstanding of single words relatively intact
Preserved Object KnowledgeObject recognition maintained
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Knowledge Graph

Related Hypotheses (3)

Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Extracellular Matrix Stiffness Modulation
Score: 0.69
Complement C1q Subtype Switching
Score: 0.66

Related Analyses (11)

RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (18)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an
validation · proposed · Score: 0.40
Progranulin Replacement Therapy for FTD — Vector Development
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40

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