| ALS incidence | 1-2 per 100,000 person-years globally |
| FTD incidence | 4-15 per 100,000 persons aged 45-64 years |
| FTD-ALS overlap | 5-15% of ALS patients have comorbid FTD |
| Gender distribution | Male predominance (1.3-1.5:1 for ALS; 1:1 for FTD) |
| Age of onset | Typically 50-65 years for both conditions |
| Normal repeats | <30 |
| Pathological repeats | >30 (typically 60-1000) |
| Penetrance | Age-dependent, with most carriers developing symptoms by age 80 |
| Mechanisms | Three proposed pathogenic mechanisms: |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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