| Gene Symbol | ent-gene-8c4b5215 |
| Blood GFAP | Moderately elevated in PD |
| Diagnostic accuracy | AUC 0.78-0.85 for AD vs controls |
| Prognostic value | Higher levels predict faster cognitive decline |
| Detects early | Elevated CSF GFAP detectable years before clinical symptoms |
| Differentiates synucleinopathies | Higher in MSA than PD (AUC 0.82) |
| Progression marker | Levels correlate with disease severity (UPDRS) |
| CSF GFAP | Intermediate elevation between PD and MSA |
| Pattern | Similar to PSP with moderate elevations (40-60 ng/mL in CSF) |
| Differential diagnosis | Helps distinguish from AD and DLB |
| Astrocytic plaques | CBD-specific pathology correlates with GFAP |
| PSP-RS correlation | Higher levels correlate with greater clinical severity |
| Diagnostic utility | Differentiates PSP from PD (AUC 0.82) |
| Midbrain atrophy | GFAP correlates with imaging measures |
| PSP Rating Scale (PSP-RS) | Positive correlation with CSF GFAP |
| UPDRS (PD) | Levels associate with motor severity |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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