| Duration of exposure | Longer careers correlate with increased risk |
| Age of first exposure | Younger age at first exposure to head impacts |
| Number of concussions | More severe and frequent traumatic brain injuries |
| Boxing style | Preference for head punches increases exposure |
| Tau-positive neurofibrillary tangles | Distributed in depths of cortical sulci |
| Neuropil threads | Widespread throughout cortical layers |
| Amyloid plaques | Present in approximately 30-40% of cases |
| Brain atrophy | Particularly in frontal and temporal lobes |
| White matter rarefaction | Due to chronic axonal injury |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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