| Contact sport athletes | American football players, boxers, hockey players, soccer players, and rugby players show the highest prevalence |
| Military veterans | Those exposed to blast injuries and repetitive concussive events |
| Physical abuse victims | Individuals with a history of repeated head trauma |
| Duration of exposure | Number of years participating in contact sports |
| Number of concussions | Total lifetime concussive and subconcussive impacts |
| Age of first exposure | Earlier age of initial head trauma exposure correlates with worse outcomes |
| Genetic factors | APOE ε4 allele may increase susceptibility[@mayeux2015] |
| Distribution | Initially affects the superficial cortical layers (II-III), then spreads to deeper layers |
| Regional pattern | Preferentially affects frontal and temporal cortices, with relative sparing of the hippocampus early in disease |
| Perivascular pattern | p-tau aggregates around blood vessels, particularly in the depths of cortical sulci |
| Neuronal preference | Affects neurons preferentially over glial cells, unlike chronic traumatic encephalomyelopathy |
| Astrocytic tau | Astrocytic tau pathology is a characteristic feature |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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