| Gene Symbol | ent-gene-364237ce |
| N-terminal extracellular domain | Single glycosylated asparagine |
| Seven transmembrane domains (TM1-TM7) | Characteristic GPCR bundle |
| Third intracellular loop | Gi/o coupling interface, serine/threonine-rich |
| C-terminal intracellular domain | Palmitoylation sites, PDZ interactions |
| Human 5-HT1A | 421 amino acids |
| Rodent orthologs | High sequence conservation (>90%) |
| Isoforms | Alternative splicing generates variants |
| Dorsal raphe nucleus (DRN) | Highest density of 5-HT1A autoreceptors |
| Median raphe nucleus (MRN) | Secondary serotonergic cell body region |
| Mesencephalic raphe | Midbrain serotonergic populations |
| Raphe magnus | Descending pain modulation |
| CA1 pyramidal neurons | Highest hippocampal expression |
| CA3 pyramidal neurons | Moderate density |
| Dentate gyrus granule cells | Lower expression |
| Hilus | Interneuron populations |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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