| Gene Symbol | ent-gene-545acd83 |
| Chromosome | 3q13.3 |
| Function | - Motor sequence learning |
| NCBI Gene ID | 1817 |
| Protein length | 400 amino acids |
| Molecular weight | ~44 kDa |
| G protein coupling | Gi/Go - inhibits adenylate cyclase, reduces cAMP production |
| Extracellular N-terminus | ligand binding domain |
| Intracellular C-terminus | G protein coupling and phosphorylation sites |
| Third intracellular loop | critical for G protein coupling selectivity |
| cAMP/PKA pathway | Gi-mediated inhibition of adenylate cyclase |
| MAPK/ERK pathway | activation of extracellular signal-regulated kinases |
| PI3K/Akt pathway | downstream neurotrophic effects |
| β-arrestin recruitment | alternative signaling and receptor desensitization |
| Nucleus accumbens (NAc) | core and shell regions |
| Substantia nigra pars compacta (SNc) | dopaminergic cell bodies |
| Databases | GeneCardsUniProtHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!